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Pharmacokinetics of GW274150 and GW273629 in healthy rats and mice following intravenous dosing
| Compound | Species | Dose (mg kg−1) | AUC∞ (h*μg ml−1) | Cmax (μg ml−1) | Tmax (h) | T1/2 (h) | CL (l h−1 kg−1) | Vss (l kg−1) |
|---|---|---|---|---|---|---|---|---|
| GW274150 | Mouse | 1 | 6.0 | 1.6 | 0.08 | 5.7 | 0.17 | 1.32 |
| Rat | 10 | 74.2 | 13.4 | 0.08 | 6.5 | 0.14 | 1.04 | |
| GW273629 | Mouse | 10 | 15.5 | 49.1 | 0.08 | 0.14 | 0.65 | 0.11 |
| Rat | 10 | 25.9 | 36.7 | 0.08 | 3.0 | 0.39 | 0.65 | |
n=3 mice per time point (males) and n=4 rats per time point (two males and two females).
