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Role of PKA in cytoprotection mediated by PGI2. Megakaryocytes were preincubated for 30 min with PKI (100 nM) before PGI2 (3 μM) and NO donor (100 μM PAPA/NO). Apoptosis was evaluated by detection of hypodiploid nuclei in the CD41+ population 18 h later (n=4 in duplicate). *P<0.05 vs none; #P<0.05 vs NO; ¶P<0.05 vs PGI2+NO.
