Figure 2.

COX-2 is crucial in resolution of inflammation. Panel a shows the change in paw volume in wild-type and COX-2-deficient mice of a 1-week period after subplantar injection of carrageenan. Note that the edema resolves in the wild-type mice, but not in the COX-2-deficient mice (Wallace et al., 1998). Panel b shows survival of rats after induction of colitis with trinitrobenzene sulfonic acid. The rats were treated with vehicle or a COX-inhibitor twice daily for 1 week after induction of colitis (Reuter et al., 1996). Equieffective anti-inflammatory doses of the COX inhibitors were used. The rank order of selectivity for COX-2 is L745,337>etodolac>nabumetone.