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TRPC5 channel is resistant to conventional Ca2+ channel blockers. (a) Ca2+ imaging data showing no effect of bath-applied methoxyverapamil (D600, 10 μM) in Tet+ or Tet− cells, which were TG-pretreated. (b) No effect of nifedipine (1 μM) on TRPC5 in Tet+, TG-pretreated cells. (c–d) Typical examples of berberine (25 μM) and MRS 1845 (100 μM) on the whole-cell current of TRPC5 activated by Gd3+ (10 μM). Insets show the IV curves at the corresponding points (filled circles).
