Table 1.
NMDA, L- and D-aspartate activities at recombinant AMPAR expressed in Xenopus laevis oocytes
| Stimulation drugs | % of the control current | |||
|---|---|---|---|---|
| GluR1o | GluR2(Q)i | GluR3o | GluR3i | |
| 1 mM NMDA | NR (13)** | ND | ||
| 1 mM D-aspartate | 1.2±0.7 (14)** | ND | ||
| 1 mM L-aspartate | 34±2 (7) | 16±2 (4) | 44±6 (2) | 23±3 (6) |
| NMDA (1 mM)+L-glutamate (10 μM) | 64±6 (21)** | ND | ||
| D-aspartate (1 mM)+L-glutamate (10 μM) | 70±1 (8) | 32±2 (6) | 79±10 (2) | 37±2 (6) |
| L-aspartate (1 mM)+L-glutamate (10 μM) | 111±3 (22)** | ND | ||
Data are expressed as % of control. 100% control is the current response to 10 μM L-glutamate on the recombinant AMPA receptors. ND=not determined; NR=no response. Values are given as means±s.e.m. N value is indicated in parentheses.
**
These data were pooled from GluR1o, GluR2(Q)i and GluR3o as there was no statistically significant difference between the data to the different subtypes of AMPA receptors by one-way ANOVA.