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Effect of a chymase inhibitor on chymase activity and chymase-4 mRNA level in the skin tissues of Tsk and control C57B/6J mice. Chymase activity (a) and chymase-4 mRNA level (b) of Tsk and control C57BL/6J mice were measured after 2 weeks treatment with vehicle or SUN-C8257. White bars indicate the data of vehicle-treated mice (Vehicle) and black bars indicate the data of mice treated with SUN-C8257 (SUN). Vertical bars represent s.e.m. *P<0.05. NS=not significant.
