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. 2005 Apr 11;145(4):441–448. doi: 10.1038/sj.bjp.0706215

Figure 3.

Figure 3

Increased production of IL-12 after inhibition of ERK1/2 signaling. Murine macrophages (0.5 × 106 cells/well) were pretreated with PD98059 (10 μM) 1 h before LPS (50 ng ml−1), in the absence or presence of JWH-133 (100 nM) and the supernatants were harvested after 24 h and analyzed by ELISA for IL-12p40 production. The results shown are the mean±s.e.m. of three independent experiments performed in triplicate. Statistics: *P<0.001 vs control; +P<0.001 vs LPS; #P<0.001 vs LPS; ΔP<0.01 vs LPS+JWH-133.