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Effect of ethanol on desensitization of ATP-activated current mediated by the H241A mutant of rat P2X4 receptors expressed in HEK 293 cells. Current traces illustrating the desensitization of current in the presence of 30 μM ATP in the absence and presence of 50 mM EtOH. The desensitization time-constant (τd) values are those obtained for the records shown. The inset shows the normalized currents. ATP was applied with a piezoelectric device (see Methods).
