Figure 7.
Effect of purinoceptor antagonists on ethanol inhibition of ATP-activated current in the H241A mutant of rat P2X4 receptors expressed in Xenopus oocytes. (a) Records of current activated by 1 μM ATP and its inhibition by 50 mM EtOH in the absence and the presence of 10, 50 and 100 μM PPADS. All records are from the same cell. PPADS was preapplied for 6 min before the coapplication of ATP or ATP plus EtOH. (b) Records of current activated by 1 μM ATP and its inhibition by 50 mM EtOH in the absence and the presence of 10, 50 and 100 μM suramin. All records are from the same cell. Suramin was co-applied with ATP or ATP plus EtOH.