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SB-706375 inhibits [125I]hU-II binding at the native human UT receptor endogenously expressed in the rhabdomyosarcoma cell line SJRH30
| Ki (nM) | nH | |
|---|---|---|
| Competition binding | ||
| SB-706375 | 5.4±0.4 | 0.88±0.07 |
| Human U-II | 0.5±0.1 | 0.98±0.16 |
| Goby U-II | 0.6±0.2 | 0.89±0.08 |
All values are represented as mean±s.e.m. (n=4, duplicate determinations).
