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Inhibition of [3H]SB-657510 binding to monkey UT-HEK293 cell membranes by nonpeptide sulphonamide antagonists (SB-706375 and SB-657510) and native U-II isopeptides
| KD (nM) | Bmax (fmol mg−1 protein) | |
|---|---|---|
| Saturation binding | ||
| [3H]SB-657510 | 2.6±0.4 | 860±120 |
| Ki (nM) | nH | |
| Competition binding | ||
| SB-706375 | 4.6±1.3 | 0.99±0.05 |
| SB-657510 Ki | 17.6±5.4 | 0.89±0.03 |
| Human U-II Ki | 11.4±3.3 | 1.16±0.15 |
| Goby U-II Ki | 14.6±4.3 | 0.96±0.12 |
All values are represented as mean±s.e.m. (n=3–4, duplicate determinations).
