Table 2.

The effect of drugs on phase 1 and phase 2 VF in the same animals in vivo

Drug	Species	Anaesthesia	Dose	Reduction of phase1 VF?	Reduction of phase2 VF?
Class I drugs
Lidocaine1	Rat	None	2 mg kg− 1 i.v.	Yes	Yes
Lidocaine2	Rat	Pentobarbitone	10 mg kg− 1 + 5 mg kg− 1 h− 1 i.v.	Yes	No
Quinidine3	Rat	None	20 mg kg− 1 i.v.	Yes	No
Disopyramide3	Rat	None	10 mg kg− 1 i.v.	No	No
Mexiletine4	Rat	None	20 mg kg− 1 i.v.	Yes	No
Quinacainol5	Rat	None	4 mg kg− 1 i.v.	Yes	No
Class II drugs
Labetalol6	Rat	None	5 mg kg− 1 i.v.	No	No
Oxprenolol7	Rat	Pentobarbitone	50 mg kg− 1 p.o. b.i.d	Yes	No
Pindolol1	Rat	None	15 μg kg− 1 i.v.	Yes	Yes
Propranolol6	Rat	None	0.2 mg kg− 1 + 0.1 μg kg− 1 min− 1 i.v.	No	No
Class III drugs
Tedisamil8	Rat	None	2 mg kg− 1 i.v.	Yes	No
Class IV drugs
Nifedipine9	Rat	None	0.5, 2 mg kg− 1 i.v.	Yes	No
Nifedipine9	Rat	None	10 mg kg− 1 i.v.	Yes	Yes
Verapamil10	Rat	None	20 mg kg− 1 i.v.	Yes	No
Felodipine11	Rat	None	4 mg kg− 1 i.v.	No	No
Anipamil12	Pig	Pentobarbitone	5 mg kg− 1 + 0.5 mg kg− 1 min− 1	No	No
Miscellaneous interventions
Blood K+ elevation13	Rat	None	A range of KCl infusions	Yes	Yes
Nafazatrom14	Rat	Ether	100 mg kg− 1 b.i.d.	No	Yes
Aspirin15	Rat	None	100 mg kg− 1 i.v.	No	No

Data are taken from: (1) (Lepran et al. (1983), (2) Clark et al. (1980), (3) Johnston et al. (1983a, 1983b), (4) Igwemezie et al. (1992), (5) Howard et al. (1992), (6) Botting et al. (1983), (7) Campbell et al. (1984), (8) Beatch et al. (1991), (9) Curtis & Walker (1988), (10) Curtis et al. (1984), (11) Curtis et al. (1985a). (12) Pugsley et al. (1995), (13) Saint et al. (1992), (14) Fiedler, (1983), (15) Johnston et al. (1983a, 1983b).