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(a, b) Two different experimental time protocols outlined with a common 60 min initial equilibration period with 95% O2/5% CO2 (hyperoxia), followed by gas mixture change to 95% N2/5% CO2 (hypoxia) in group B and 21% O2/5% CO2/74% N2 (normoxia) in group C, whereas group A continues with 95% O2/5% CO2 (hyperoxia). Arrows or abbreviations indicate the addition of KCl (K1–3), endothelin 1 (ET-1), agonist (αCGRP, AM or AMY), antagonist (αCGRP8–37) and substance P (SP).
