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. 2005 Apr 18;145(5):656–663. doi: 10.1038/sj.bjp.0706233

Figure 1.

Figure 1

Original traces of currents elicited by 100 ms pulses of 10 mM glutamate (glu) or 10 mM glutamate+the respective IEM-1460 concentration after preincubation of outside-out patches from HEK293 cells transfected with human GluR2 flip GQ (a), GluR2 flip GR channels (d) and of currents elicited by 200 ms pulses of 10 mM glutamate and 0.1 mM cyclothiazide with or without IEM-1460 of human GluR2 flip GQ channels (b). The straight lines (a) show the time course of desensitisation fitted by a single exponential. The middle right column (c) shows original traces of currents elicited by 100 ms pulses of 10 mM glutamate or 10 mM glutamate+the respective IEM-1460 concentration from HEK293 cells transfected with human GluR2 flip GN at different holding potentials as indicated. Values of τD and τB are indicated. The holding potential was −60 mV when not stated otherwise.