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. 2005 Apr 18;145(5):656–663. doi: 10.1038/sj.bjp.0706233

Figure 4.

Figure 4

Dose-inhibition experiments with IEM-1460 at nondesensitizing GluR2L504Y channels. (a) Original traces of currents elicited by 100 ms pulses of 10 mM glutamate or 10 mM glutamate+the respective IEM-1460 concentration after preincubation of outside-out patches from HEK293 cells transfected with GluR2 L504Y channels with different concentrations of IEM-1460 as indicated (the τB values of the respective experiments are indicated). (b) The average values of τB were plotted vs the respective IEM-1460 concentration (see Figure 2a for the values of the relative steady-state current amplitudes). The holding potential was −60 mV at all experiments.