Table 1.
Inhibitory effects of drugs on EFS-induced contractions in detrusor strips
| Compound | n | Human | n | Pig | n | Mouse |
|---|---|---|---|---|---|---|
| Propiverine NS | 5 | 5.44±0.56 | 8 | 4.73±0.12 | 8 | 5.09±0.09 |
| M-5NS | 6 | 4.14±0.11 | 6 | 3.90±0.15 | 8 | 3.89±0.11 |
| M-6 | 7 | 7.05±0.15** | 13 | 5.38±0.34 | 8 | 4.69±0.31 |
| M-14NS | 6 | 4.40±0.29 | 16 | 4.24±0.23 | 8 | 4.69±0.11 |
| AtropineNS | 5 | 7.60±0.38 | 18 | 7.82±0.08 | 15 | 7.85±0.10 |
Data expressed as −log IC50 values (means±s.e.m.; IC50 in M). n, number of experiments.
NS – no statistical significant differences between the three species.
**
P<0.01 for −log IC50 value in man vs pig and mouse.