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. 2005 May 9;145(6):792–799. doi: 10.1038/sj.bjp.0706242

Figure 1.

Figure 1

(a) Dose dependence of glutamate preincubation (60 min). EC50=42 μM; n=7. (Inset) Glutamate (100 μM) preincubation for 60 min (stimulated) induced ∼90% increase in sodium-dependent platelet glutamate uptake (+Na) with respect to glutamate-free medium preincubated samples (basal). Glutamate failed to stimulate glutamate uptake when incubated in Na-free medium (−Na). ***P<0.0005 vs +Na/basal, °°°P<0.0005 vs +Na/stimulated, Student's t-test; n=25. (b) Time course of glutamate preincubation (100 μM). A significant increase in glutamate uptake with respect to basal levels occurred after ∼30 min (**P<0.001, Bonferroni test) and reached the maximal value after ∼90 min (***P<0.0005, Bonferroni test); n=4.