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. 2005 May 9;145(6):792–799. doi: 10.1038/sj.bjp.0706242

Figure 3.

Figure 3

(a) Effects of preincubation with glutamate receptor agonists or antagonists (60 min, in bold) on platelet glutamate uptake. NMDA (100 μM), MK801 (100 μM), kainate (KA; 100 μM) or CNQX (100 μM) preincubation all failed to modulate basal and stimulated glutamate uptake. Only preincubation with the metabotropic receptor antagonist MCPG (200 μM) appeared to reduce glutamate-stimulated uptake. ***P<0.0001 vs CTRL/basal, °P<0.02 vs CTRL/stimulated, Bonferroni test; n=7. (b) Effects of preincubation with glutamate analogues (60 min) on glutamate uptake. Platelets preincubated with D-aspartate (100 μM, Asp) showed a significant increase in glutamate transport, although this was weaker than that elicited by preincubation with equimolar glutamate concentrations (Glu). ***P<0.0001 vs CTRL, °P<0.01 vs Glu, Bonferroni test; n=7. Preincubation with SOS (200 μM), THA (500 μM) or DHK (500 μM) failed to induce any increase in glutamate transport.