Figure 1.
Induction of giant mepps by 4-AQA (30 μM). (a) Consecutive examples of the mepps recorded following 15 min in the presence of 4-AQA. (b, c) Amplitude histograms of the mepps recorded from this endplate (b) before and (c) following 15 min in the presence of 30 μM 4-AQA. Insets show the same data expressed as column graphs with the number of normal mepps with amplitudes less than twice the mode (meppN) and the number of mepps with amplitudes greater than twice the mode mepp>2M and the number of mepps with amplitudes greater than three times the mode (mepp>3M) plotted, providing a further measure of the distribution of the giant mepps. The data shown were obtained from a single endplate; each recording period was 418.5 s in duration; Vm=−96 mV.