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Effect of PDBu (100 nM) on normal and giant mepps in the presence of 4-AQA (30 μM). mepp amplitude histograms recorded in the presence of 30 μM 4-AQA before (a, control) and after application of 100 nM PDBu (b) are shown. Insets show the same data expressed as column graphs. As shown, PDBu increased the number of all mepps. The data shown were obtained from a single endplate; each recording period was 418.5 s in duration; Vm=−86 mV.
