Figure 6.

The EPSC depressing effect of E139 is occluded by pretreatment with γ-vinyl GABA (γvG), an irreversible GABA transaminase inhibitor. (a) A representative time–effect plot of the effect of 500 μM γvG on evoked EPSCs and the subsequent application of E139 showing no additional synaptic depression. (b) A normalized averaged time–effect plot obtained from four cells that received the above treatment. (c) A summary bar graph of the effect of 500 μM γvG and the lack of effect of E139 in the presence of γvG. This graph also summarizes the blockade of γvG effect in four additional cells that were pretreated with 1 μM CGP55845 prior to γvG.