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Inhibition by lipids of [3H]P1075 and [3H]GBC binding to SUR2A and SUR2A(YS) in the presence of MgATP (0.3 mM)
| SUR | Radioligand | Lipid (μM) | Binding (% BS) (n) |
|---|---|---|---|
| SUR2A | [3H]P1075 | PIP2, 100 | 98±15a (7) |
| DOGS-NTA, 100 | 49±7 (6) | ||
| Oleoyl-CoA, 100 | 4±1 (4) | ||
| Malonyl-CoA, 300 | 64±7 (4) | ||
| Oleate, 300 | 14±3 (3) | ||
| SUR2A(YS) | [3H]GBC | DOGS-NTA, 100 | 50±4 (6) |
| Oleoyl-CoA, 100 | 38±13 (4) |
(n) denotes the number of experiments.
At 30 μM PIP2, stimulation of binding to 117±8% was observed.
