Figure 4.

HPLC chromatograms showing the metabolism of VDM11 (400 μM) following preincubation with CAY10401 at concentrations of 10 nM (a), 100 nM (b) or 1 μM (c). For experimental and digital treatment details, see legend to Figure 3. The retention times were slightly longer in these experiments, but this was also seen for a sample run concurrently but with 4-amino-m-cresol (100 μM) rather than VDM11 (data not shown).