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. 2005 May 23;145(7):872–879. doi: 10.1038/sj.bjp.0706257

Figure 1.

Figure 1

(a) Stress enhances neutrophil recruitment in male rats: sympathoadrenal- and β-adrenergic receptor-dependence. Basal (saline) levels of neutrophils in the air pouch were not affected by stress. LPS increase recruitment of neutrophils compared to saline, and compared to nonstressed rats (LPS), sound stress enhanced LPS-induced neutrophil recruitment (LPS+stress). The effect of stress was abolished by adrenal denervation (LPS+stress+Ad-Den) or by chronic administration of the β-adrenergic receptor antagonist, propranolol (LPS+stress+prop.). Administration of the β-adrenergic receptor agonist isoproterenol (LPS+isoprot.) mimicked the effect of stress. Results are expressed as mean±s.e.m. (n, indicated on the graph). Significance differences (P<0.05) are indicated by *; NS indicates no significant difference. (b) Stress has no effect on neutrophil recruitment in female rat. Basal (saline) levels of neutrophils in the air pouch were not affected by stress. LPS increase recruitment of neutrophils compared to saline, but compared to nonstressed rats (LPS), sound stress had no effect. Chronic administration of the β-adrenergic receptor antagonist, propranolol in naïve females (LPS+prop.) significantly enhanced the recruitment of neutrophils compared to naïve rats, but neutrophil recruitment in stressed rats was not affected by chronic propranolol. Administration of the β-adrenergic receptor agonist isoproterenol (LPS+isoprot.) was not significantly different from LPS alone. Results are expressed as mean±s.e.m. (n, indicated on the graph). Significance differences (P<0.05) are indicated by *; N.S. indicates no significant difference.