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. 2005 May 23;145(7):984–991. doi: 10.1038/sj.bjp.0706268

Figure 1.

Figure 1

Effects of U50 in the presence of nor-BNI, 5 μM or Pax on myocardial infarct (a) or LDH release (b) in the isolated perfused rat heart subjected to ischaemia for 30 min and reperfusion for 120 min. Experimental protocol is shown in the upper panel. Hearts were pretreated with 10 μM U50 interspersed with 5 min drug-free perfusion. nor-BNI (5 μM) was administered for 30 min before ischaemia. Pax (1 μM) was either administered for 30 min before ischaemia (PaxT) or throughout the ischaemia and 15 min after start of reperfusion (PaxM). Data are expressed as individual values and mean±s.e.m.; n=10 in each group. **P<0.01 vs the IR group.