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Cumulative CRC to (a) NaHS, (b) capsaicin (Caps) and (c) SP following capsaicin desensitization (Caps Des, 10 μM twice for 20 min, 30 min before the stimulus) or vehicle (veh) pretreatment. Each entry represents the mean±s.e.m. value of at least six experiments (*P<0.05 vs veh).