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. 2005 Jun 13;145(8):1045–1051. doi: 10.1038/sj.bjp.0706283

Table 1.

Biodistribution studies of [11C]carvedilol in male Wistar rats 60 min post injection, expressed as DAR

  CsA dosage (mg kg−1)
Organ 0 (n=5) 5 (n=5) 10 (n=3) 15 (n=5) 25 (n=3) 50 (n=3)
Brain* 0.12 (0.06) 0.12 (0.09) 0.12 (0.07) 0.21 (0.19) 0.62 (0.19) 0.64 (0.38)
Heart 0.66 (0.13) 0.52 (0.19) 0.43 (0.16) 0.60 (0.33) 0.77 (0.22) 0.67 (0.45)
Lung 6.08 (2.58) 3.81 (1.47) 3.14 (1.91) 3.34 (1.69) 6.48 (1.81) 5.00 (3.83)
Liver 3.02 (1.58) 3.10 (2.34) 2.30 (1.39) 2.59 (1.73) 3.19 (1.49) 2.45 (1.87)
Kidney 1.33 (0.49) 1.01 (0.34) 0.81 (0.43) 1.02 (0.61) 2.34 (1.47) 1.92 (1.52)
Testis 0.28 (0.23) 0.30 (0.20) 0.24 (0.12) 0.18 (0.13) 0.30 (0.10) 0.37 (0.25)
Plasma 0.41 (0.31) 0.43 (0.30) 0.40 (0.36) 0.39 (0.33) 0.74 (0.48) 0.53 (0.19)

*P=0.003.