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. 2005 Jun 20;145(8):1153–1159. doi: 10.1038/sj.bjp.0706297

Figure 1.

Figure 1

Effect of carbachol on the evoked overflow of tritium from atria of M3-wild-type or M3-knockout (a), M2/4-wild-type or M2/4-knockout (b), and M2/3-wild-type or M2/3-knockout (c) mice. After preincubation with 3H-noradrenaline, tissues were superfused and stimulated six times by 20 pulses at 50 Hz (S1–S6). Carbachol was added at increasing concentrations (abscissae) before S2–S6. Ordinates, evoked overflow of tritium, calculated from Sn/S1 ratios and expressed as a percentage of the corresponding control (no carbachol). Means±s.e.m. from n=6–14 tissue pieces. Significant differences from corresponding control (no carbachol): #P<0.05. Significant differences from corresponding wild type: *P<0.05.