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Effects of topiramate treatment on NO-induced dilation. Following control responses to sodium nitroprusside infusion, rats were injected with topiramate (a) 10 mg kg−1 or (b) 30 mg kg−1, and sodium nitroprusside infusion repeated after 5, 15, 30 and 60 min. *P<0.05, significance compared to the control response. #P<0.05 significance compared to the response 15 min post topiramate injection. χP<0.05, significance compared to the response 5 min post topiramate injection.
