Table 1.
Effects of 30 mg kg−1 topiramate on neurogenic dural vasodilation
| Neurogenic dural vasodilation | Increase in dural vessel diameter (% age change) |
|---|---|
| Control response | 135.6±10% |
| 5 min post 30 mg kg−1 TPM | 106.7±12%a (t5=4.56, n=6) |
| 10 min post | 85.9±5%a (t5=6.23, n=6) |
| 15 min post | 65.3±6%a (t5=6.78, n=6) |
| 30 min post | 74.0±7%a (t5=7.61, n=6) |
| 60 min post | 104.7±12%a (t5=3.05, n=6) |
| b (t5=3.39, n=6) | |
| 90 min post | 113.5±13%b (t5=2.94, n=6) |
TPM=topiramate.
a
P<0.05, significance compared to control response.
b
P<0.05, significance compared to vasodilation 15 min post TPM injection.