Table 2.
Effects of 30 mg kg−1 topiramate on NO-induced dilation
| NO-induced dilation | Increase in dural vessel diameter (% age change) |
|---|---|
| Control response | 143.3±9% |
| 5 min post 30 mg kg−1 TPM | 89.4±13%a (t6=4.55, n=7) |
| 15 min post | 84.6±10%a (t6=6.09, n=7) |
| 30 min post | 103.2±12%a (t6=2.58, n=7) |
| 60 min post | 127.7±11%b (t6=2.49, n=7) |
| c (t6=3.35, n=7) |
TPM=topiramate
a
P<0.05, significance compared to control response.
b
P<0.05, significance compared to vasodilation 15 min post TPM injection.
c
P<0.05, significance compared to vasodilation 30 min post TPM injection.