Table 4.

Effect of topiramate on the hypotensive effects of sodium nitroprusside

Mean arterial blood pressure and decreases (mmHg) after SNP infusions (4–8 μg kg−1)
Pretreatment	10 mg kg−1 TPM		30 mg kg−1 TPM
	Baseline BP	BP drop	Baseline BP	BP drop
SNP control	124.2±7	53.4±10	108.3±8	43.7±7
Post TPM 5 min	122.4±6	50.0±8	122.7±7	40.5±5
Post TPM 15 min	121.3±8	48.0±8	119.3±7	42.9±7
Post TPM 30 min	119.0±8	48.9±10	118.6±7	46.9±8
Post TPM 45 min	115.3±7	41.8±10	116.3±6	39.9±9

BP=blood pressure.

TPM=topiramate.

SNP=sodium nitroprusside (a NO donor).