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. 2005 Jun 20;146(1):129–138. doi: 10.1038/sj.bjp.0706295

Figure 4.

Figure 4

Effects of forskolin on IBa in the presence of PKA inhibitors (Rp-cAMP and PKA-IP). The PKA inhibitor Rp-cAMP (100 μM) potentiated the amplitude of IBa and abolished the inhibitory effect of 100 nM forskolin. (a) Inward current were again elicited by voltage steps (1 s duration) to +10 mV from a holding potential of −70 mV every 20 s. Typical current traces are shown in (b), at the points ((i)–(iii)) indicated in (a). The cell capacitance was 36 pF. The change in the peak amplitude of IBa as a function of time caused by 100 nM forskolin when PKA-IP (1 μM) was included in the pipette solution is shown in (c). Time 0 indicates the time when a conventional whole-cell configuration was established. The cell capacitance was 34 pF.