Table 1.
Effects of SP and CA on the characteristics of hKv1.5, Kv4.3 and Kv7.1+minK currents
| Current | ||||||
|---|---|---|---|---|---|---|
| hKv1.5 | Control | SP (1 μM) | Control | CA (1 nM) | Control | CA (500 μM) |
| τf deactivation (ms) | 25.9±4.9 | 38.5±7.3* | 30.2±2.6 | 48.9±5.1** | 34.3±7.1 | 77.2±26.1** |
| τs deactivation (ms) | 105.1±24.3 | 160.8±39.9* | 103.5±15.4 | 154.8±24.6 | 95.9±5.0 | 275.1±42.3* |
| Vh activation (mV) | −13.1±0.5 | −19.8±2.2* | −11.0±1.6 | −15.3±2.3** | −9.0±1.6 | −14.1±0.1** |
| kactivation (mV) | 4.6±0.8 | 5.4±1.0* | 5.0±0.3 | 4.9±0.3 | 4.7±0.2 | 4.9±0.4 |
| Kv4.3 | Control | SP (1 μM) | Control | CA (1 nM) | Control | CA (100 nM) |
| τf inactivation (ms) | 21.1±3.8 | 15.4±2.8* | 18.6±4.3 | 11.6±2.6* | 18.9±1.7 | 9.1±1.2** |
| Vh inactivation (mV) | −33.5±1.1 | −35.5±1.2 | −37.0±1.8 | −40.8±1.6* | −31.8±1.7 | −42.0±2.1** |
| kinactivation (mV) | 5.4±0.1 | 5.7±0.2 | 5.4±0.4 | 5.5±0.3 | 5.4±0.4 | 5.3±0.2 |
| Kv7.1+minK | Control | SP (10 μM) | Control | CA (1 nM) | Control | CA (100 nM) |
| Vh activation (mV) | 17.1±4.3 | 18.7±4.8 | 16.9±4.2 | 15.9±4.0 | 29.4±2.4 | 28.2±7.1 |
| kactivation (mV) | 12.1±3.0 | 14.8±1.9 | 14.8±0.8 | 14.5±1.1 | 13.4±1.6 | 12.2±1.1 |
| τf deactivation (ms) | 189±54 | 212±52 | 155±30 | 135±39 | 252±24 | 313±80 |
| τs deactivation (ms) | 812±154 | 1126±230* | 1039±297 | 963±161 | 776±174 | 1941±490* |
Data are mean±s.e.m. of 6–8 experiments. *P<0.05 and **P<0.01 vs control, respectively.