Table 2.

IC₅₀, n_H and B_max values obtained in the presence of CA on hKv1.5, Kv4.3 and Kv7.1+minK channels

Current	Index of block	IC50	nH	Bmax (%)
hKv1.5	+60 mV	173.5±21.6 μM	1.5±0.4	80.4±4.1
	0 mV	147.9±17.1 μM	2.0±0.7	77.1±4.3
	Tail at +60 mV	135.8±17.7 μM	1.8±0.8	78.7±5.7
Kv4.3	+50 mV	17.2±7.4 nM	0.6±0.2	79.9±21
	0 mV	2.6±1.3 nM	1.6±1.1	53.5±4.4
	Pulses to −30 mV	40.6±16.1 nM	0.4±0.06	93.3±4.7
Kv7.1+minK	+40 mV	22.3±7.9 nM	0.3±0.4	78.9±28.8
	0 mV	29.6±18.0 nM	3.0±3.3	45.8±2.3
	Tail at +40 mV	0.7±0.4 μM	0.5±0.6	82.2±31.7

In hKv1.5 channels, the indexes of block used were the inhibition at the end of pulses to +60 and 0 mV, and of the tails recorded upon repolarisation to −40 mV after pulses to +60 mV (tail at +60 mV). In Kv4.3 channels, the indexes used were the reduction in the charge crossing the membrane after pulses to +50 and 0 mV, and in the peak current at +40 mV elicited after pulses to −30 mV (pulses to −30 mV). In Kv7.1+minK channels, the indexes of block used were the inhibition of the current at the end of pulses to +40 and 0 mV, and of the tail currents recorded upon repolarisation to −40 mV after pulses to +40 mV (tail at +40 mV). Data are mean±s.e.m. of >5 experiments.