Figure 9.

Effect of W-212393 on re-entrainment of the body temperature rhythm to a 6 h advanced light–dark cycle. (a) Representative records of the effects of vehicle (V) and W-212393 (W) injected at ZT6. The time of day is indicated horizontally and consecutive days vertically. Upper, middle, and lower bars on top of the figure show the light (open bar)–dark (solid bar) cycle during days 1–13, 14–34, and 35–46, respectively. Asterisk in the figure indicates the time of injections. (b) The mean phase shifts plotted each day after a 6 h advanced light–dark cycle. Data indicate the mean±s.e.m. of seven rats (crossover administration). ^*P<0.05, ^**P<0.01, ^***P<0.001 in comparison with vehicle by paired Student's t-test.