Figure 3.

Blockade of Amadori-induced stimulation of NF-κB-related proinflammatory factors by PDTC. (a) HPMCs were treated for 12 h with HHb (10 nM) or gBSA (0.25 mg ml⁻¹) either alone or in combination with PDTC (100 μM) and the luciferase-based expression of human iNOS, −327/+59 human COX-2, and human IL-6 was studied in transiently transfected HPMCs. (b) NOS and COX activities were determined after HPMCs exposure to the above-described treatments, n=32. ^*P⩽0.05 vs basal; ^**p⩽0.05 vs the correspondent Amadori (gBSA or HHb)-treated cells.