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. 2005 Jul 4;146(2):306–312. doi: 10.1038/sj.bjp.0706318

Figure 1.

Figure 1

Effect of dopamine antagonists on the effect of MDMA on rectal temperature in rats at Ta 15°C. Graph shows the difference in the mean rectal temperature compared to the control group (saline/saline)±s.e.m. (n=5). MDMA (5 mg kg−1) produced a decrease in rectal temperature compared to saline-injected control animals (F(1,8)=190.84, P<0.0001), results being calculated from the raw data. Remoxipride (10 mg kg−1) itself had no effect on rectal temperature compared to control animals, and the response of rats pretreated with remoxipride before the MDMA was different from that of rats treated with MDMA (F(1,8)=31.2, P=0.0005). Administration of SCH23390 (1.1 mg kg−1) before MDMA did not significantly alter the response compared to rats given only MDMA (F(1,8)=1.54, P=0.2499).