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Cumulative dose–response curves in segments of the thoracic aorta for (a) ATP, (b) ADP, (c) UTP and (d) UDP in the presence of PPADS, a nonselective purinergic receptor antagonist. PPADS showed surmountable (UTP and UDP) or nonsurmountable (ADP) antagonism, while ATP-evoked vasodilatation was not affected. Mean±s.e.m.; n=5.
