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Apparent pKb values of different antagonists in isolated thoracic aorta and aortic root
| Tissue | Suramin | PPADS | MRS2179 |
|---|---|---|---|
| Agonist | −log(M) | −log(M) | −log(M) |
| Thoracic aorta | |||
| ATP | 4.53±0.07 | <5 | <5 |
| ADP | 5.55±0.11 | n.s. | 6.62±0.09 |
| UTP | 5.19±0.03 | 5.22±0.10 | <5 |
| UDP | 5.26±0.06 | 5.73±0.06 | <5 |
| Aortic root | |||
| ADP | 5.61±0.22 | 6.26±0.53 | 6.75±0.26 |
| UDP | 5.24±0.08 | 5.71±0.10 | <5 |
Values represent mean±s.e.m. of five mice, except for the aortic root: n=4. n.s.=nonsurmountable antagonism.
