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. 2005 Jul 11;146(3):397–407. doi: 10.1038/sj.bjp.0706330

Figure 4.

Figure 4

Mechanisms underlying PAR2-mediated anion secretion in Calu-3 cells. (a–e) Representative traces of potential differences from the basolateral to the apical side (PD) before and after application of the PAR2-activating peptide (PAR2AP, 50 μM, in the presence of the vehicle (0.1% DMSO: Control, a), U73122 (100 μM, b), xetospongin C (Xest C, 10 μM, c), D609 (100 μM, d), and PMA (1 μM, e). PD was monitored under open-circuit condition with applications of repeated short (0.5 s) current pulses (10 μA). (f) Summary of the PAR2AP-induced elevation of the equivalent short-circuit current (ΔIeq), which was calculated by PD data. U73122, Xest C, D609, and PMA were applied 30 min prior to addition of PAR2AP. Data are means±s.e.m. (n=4–7). *P<0.005, **P<0.001.