. 2005 Jul 25;146(3):408–418. doi: 10.1038/sj.bjp.0706349

Table 2.

Effect of neonatal capsaicin treatment on brain measurements of male and female rats

	Capsaicin		Vehicle		Significance of capsaicin treatment
Brain measurement	Male	Female	Male	Female
Cross-sectional area (mm²)
2.70	81.69±2.54	81.31±3.28	84.68±3.28	83.09±2.54
1.20	97.47±2.30	99.72±2.97	102.58±2.97	103.51±2.30	^*
−1.60	119.61±2.65	123.74±3.43	132.99±3.43	130.39±2.65	^*
−2.56	127.06±3.19	126.12±4.11	126.27±4.11	132.25±3.19	^*
−3.60	125.30±3.72	123.54±4.81	139.65±4.81	135.68±3.72	^**
−5.80	116.41±4.31	110.72±5.56	127.09±5.56	128.44±4.31	^*

Cortical thickness (mm)
1.20	2.15±0.07	2.06±0.06	2.35±0.07	2.16±0.05	^*
−1.60	1.72±0.06	1.82±0.05	1.79±0.06	1.72±0.04
−2.56	1.55±0.07	1.55±0.06	1.65±0.07	1.65±0.05
−3.60	1.40±0.04	1.50±0.04	1.62±0.04	1.50±0.03	^*
−5.80	1.27±0.04	1.29±0.04	1.41±0.04	1.40±0.03	^***

Ventricle area (mm²)
1.20	0.54±0.09	0.38±0.07	0.47±0.08	0.32±0.07
−1.60	0.97±0.21	1.15±0.17	0.82±0.18	0.58±0.17	^*
−2.56	0.40±0.09	0.51±0.07	0.53±0.08	0.52±0.07

Hippocampal area (mm²)
−2.56	10.05±1.07	8.73±0.96	8.86±0.96	7.83±0.96
−3.60	12.494±1.20	10.59±1.08	14.97±1.08	13.96±1.08	^*

Corpus callosum thickness (mm)
1.20	0.90±0.03^##	0.88±0.02	1.09±0.04	0.98±0.03	^***
−1.60	0.94±0.04^#	0.83±0.03	1.06±0.05	0.84±0.04
−2.56	0.77±0.04	0.66±0.04	0.86±0.06	0.73±0.04

Corpus callosum width (mm)
1.20	3.36±0.09	3.43±0.08	3.44±0.18	3.51±0.09
−1.60	2.32±0.10	2.50±0.09	2.68±0.19	2.43±0.10
−2.56	2.43±0.06	2.50±0.05	2.58±0.11	2.58±0.06

Aqueduct (mm²)
−5.80	0.18±0.02	0.15±0.02	0.09±0.02	0.08±0.02	^*

Brain levels are mm from Bregma (see text and Figure 1 for description of measurements). Values shown are means±s.e.m. obtained from five rats. Asterisks show the overall significance of capsaicin treatment, ^***P<0.001; ^**P<0.01; ^*P<0.05. Hatches show the significance of capsaicin treatment on male rats for comparisons where there was a significant effect of gender, ^##P<0.01; ^#P<0.05.