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Comparison of LARG amino acid sequence to various other proteins. Numbers refer to amino acid position of each protein. White letters in black boxes represent amino acid identity. (A) Predicted amino acid sequence of LARG relative to other PDZ-containing proteins. (B) Predicted LH domain of LARG compared with several Rho GEFs and Lsc. (C) Predicted DH domain compared with several Rho GEFs and Dbl. (D) Predicted PH domain of LARG compared with several Rho GEFs and pleckstrin.
