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Schematic representation of MLL, MLL-LARG, and LARG proteins. In LARG, the PDZ domain, LH domain, bipartite nuclear localization signal, DH domain, and PH domain are illustrated (Bottom). The predicted translocation product, MLL-LARG, is shown containing the AT hooks and methyl-CpG binding domain of MLL and the bipartite nuclear localization signal, LH, DH domain, and PH domain of LARG.
