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Treatment of EAMG in C57BL/6 mice reduces levels of antibodies specific to AChR. Anti-AChR antibody levels were measured by ELISA. Shown are results obtained with sera of individual mice (dilution 1:107) bled at the end of 4 wk of treatment with the dual analog. Dashes indicate mean anti-AChR antibody titers. Antibody titers of the dual analog-treated group are significantly lower (P = 0.005) than those of mice in the PBS-treated group.
