Abstract
The functional status of the reticuloendothelial Fc receptor in patients with Sjogren's Syndrome was examined by determining the clearance from the circulation of IgG coated erythrocytes which had been obtained from a single donor. 18 patients with Sjogren's Syndrome were studied and the results compared with those obtained from 18 patients with Rheumatoid Arthritis and 27 healthy controls. Abnormal Fc mediated clearance was observed in 3 individuals with Sjogren's Syndrome and 2 patients with Rheumatoid Arthritis. Extraglandular disease was not associated with abnormal Fc function and there was no correlation between the clearance rates and the immune complex levels, complement levels or rheumatoid factor titre. A comparison of the clearance rates obtained using the patients own red cells with those derived from using a single donor showed that the source of cells used had a significant effect on the clearance rate. Our findings provide no support for the idea that defective Fc function may be of pathogenic significance in the development of more extensive disease in patients with Sjogren's Syndrome.
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- Frank M. M., Hamburger M. I., Lawley T. J., Kimberly R. P., Plotz P. H. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med. 1979 Mar 8;300(10):518–523. doi: 10.1056/NEJM197903083001002. [DOI] [PubMed] [Google Scholar]
- Hamburger M. I., Moutsopoulos H. M., Lawley T. J., Frank M. M. Sjögren's syndrome: a defect in reticuloendothelial system Fc-receptor-specific clearance. Ann Intern Med. 1979 Oct;91(4):534–538. doi: 10.7326/0003-4819-91-4-534. [DOI] [PubMed] [Google Scholar]
- Kimberly R. P., Parris T. M., Inman R. D., McDougal J. S. Dynamics of mononuclear phagocyte system Fc receptor function in systemic lupus erythematosus. Relation to disease activity and circulating immune complexes. Clin Exp Immunol. 1983 Feb;51(2):261–268. [PMC free article] [PubMed] [Google Scholar]
- Moutsopoulos H. M., Webber B. L., Vlagopoulos T. P., Chused T. M., Decker J. L. Differences in the clinical manifestations of sicca syndrome in the presence and absence of rheumatoid arthritis. Am J Med. 1979 May;66(5):733–736. doi: 10.1016/0002-9343(79)91110-0. [DOI] [PubMed] [Google Scholar]
- ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
- Rochna E., Hughes-Jones N. C. The use of purified 125-I-labelled anti-gamma globulin in the determination of the number of D antigen sites on red cells of different phenotypes. Vox Sang. 1965 Nov-Dec;10(6):675–686. doi: 10.1111/j.1423-0410.1965.tb05179.x. [DOI] [PubMed] [Google Scholar]
- Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
- Williams B. D., O'Sullivan M. M., Ratanachaiyavong S. Reticuloendothelial Fc function in normal individuals and its relationship to the HLA antigen DR3. Clin Exp Immunol. 1985 Jun;60(3):532–538. [PMC free article] [PubMed] [Google Scholar]
- van der Woude F. J., van der Giessen M., Kallenberg C. G., Ouwehand W., Beekhuis H., Beelen J. M., van Son W. J., Hoedemaeker P. J., van der Hem G. K., The T. H. Reticuloendothelial Fc receptor function in SLE patients. I. Primary HLA linked defect or acquired dysfunction secondary to disease activity? Clin Exp Immunol. 1984 Mar;55(3):473–480. [PMC free article] [PubMed] [Google Scholar]