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The effect of IL-12 on IL-1β-induced PGE2, IL-8, and IFN-γ production in PBMC. PBMC from five donors were cultured in flat bottom wells at 5 × 106 cells/ml in RPMI and were incubated with either IL-1β (100 ng/ml), IL-12 (5 ng/ml), or the combination of these. After 48 hr, IFN-γ (A), PGE2 (B), and IL-8 (C) were measured. The data represent the fold-change ±SEM over that of the production in IL-1β-stimulated cells (set at 1). Statistical significance was calculated by paired t test.
