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Effect of IL-12 and IL-18BP on spontaneous production of PGE2. PBMC from 4 donors were cultured in flat bottom wells at 5 × 106 cells/ml in RPMI and were incubated in the absence or presence of IL-12 (5 ng/ml) or IL-18BP (100 ng/ml). PGE2 production represents the fold-change ±SEM over that in unstimulated cells (set at 1). *, P < 0.05 as calculated by paired t test.
