Figure 1.

Effects of VE on liver weight in TGFα/c-myc transgenic mice. TGFα/c-myc mice fed with control diet exhibited greater liver mass than wt mice at 4 (*P < 0.004) and 10 (*P < 0.0004) wk of age. VE dietary supplementation reversed TGFα/c-myc-induced increase in liver mass to the levels found in wt mice. After 1 wk of supplementation with VE starting at 3 wk of age, the liver/body weight ratios were only slightly reduced (P = 0.18). By 10 wk of age, the difference in liver weights between TGFα/c-myc mice fed with control or VE supplemented diet reached a statistical significance (P < 0.004). Values are expressed as percentages of total body weights ± SE (n = 5 in each group of mice).