Figure 3.

VE dietary supplementation reduced liver pathology in TGFα/c-myc transgenic mice. Representative histology of liver samples for wt (A and B) and TGFα/c-myc transgenic mice fed with control (C and D), or VE supplemented (E and F) diet at 10 and 26 wk of age. Control TGFα/c-myc livers manifest an advanced nuclear atypia and marked cellular and nuclear enlargement as compared with wt healthy livers. VE dietary supplementation markedly decreased the severity of hepatic dysplasia and reduced tumor formation. Hematoxylin and eosin staining of paraffin-embedded sections (×125 original magnification).